Mapping the circadian transcriptional machinery on chromatin
Date
Thursday, October 16, 2025 13:00 - 14:00
Speaker
Darina Barkhatova (Michael Group)
Location
Central Bldg / O1 / Mondi 2a (I01.O1.008)
Series
Seminar/Talk
Contact
Circadian rhythms are endogenous 24-hour cycles that regulate a variety of physiological processes in living organisms, with disruptions linked to multiple disorders. On the molecular level, the mammalian circadian clock is controlled by transcriptional heterodimer CLOCK-BMAL1, which controls about 15% of the entire transcriptome. The transcriptional output of CLOCK-BMAL1, however, is heterogeneous across tissues, due to the additional regulation implied by different chromatin states and tissue-specific transcriptional cofactors. The mechanisms of these modulations remain poorly explored, and in my talk, I will present how, using biochemistry and structural biology techniques, I am trying to get more details on the molecular basis of circadian transcriptional regulation in the chromatin context.