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DTSTART:20250330T030000
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DTSTAMP:20260424T040527Z
UID:68d133479d49f045371675@ist.ac.at
DTSTART:20251016T130000
DTEND:20251016T140000
DESCRIPTION:Speaker: Darina Barkhatova\nAbstract: Circadian rhythms are end
 ogenous 24-hour cycles that regulate a variety of physiological processes 
 in living organisms\, with disruptions linked to multiple disorders. On th
 e molecular level\, the mammalian circadian clock is controlled by transcr
 iptional heterodimer CLOCK-BMAL1\, which controls about 15% of the entire 
 transcriptome. The transcriptional output of CLOCK-BMAL1\, however\, is he
 terogeneous across tissues\, due to the additional regulation implied by d
 ifferent chromatin states and tissue-specific transcriptional cofactors. T
 he mechanisms of these modulations remain poorly explored\, and in my talk
 \, I will present how\, using biochemistry and structural biology techniqu
 es\, I am trying to get more details on the molecular basis of circadian t
 ranscriptional regulation in the chromatin context.
LOCATION:Central Bldg / O1 / Mondi 2a (I01.O1.008)\, ISTA
ORGANIZER:rpacarad@ist.ac.at
SUMMARY:Darina Barkhatova: Mapping the circadian transcriptional machinery 
 on chromatin
URL:https://talks-calendar.ista.ac.at/events/6063
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