Optimality for developmental robustness
Date
Thursday, April 24, 2025 14:00 - 15:00
Speaker
Takashi Hiiragi (Hubrecht Institute)
Location
Mondi Seminar Room 2, Central Building
Series
Seminar/Talk
Host
Edouard Hannezo
Contact
Tissue patterning depends on the coordination between cellular dynamics, fate specification and tissue morphogenesis. Understanding how precision in patterning is robustly achieved despite the inherent developmental variability remains a challenge. Our group aims to understand the design principle of multi-cellular organisms using early mammalian embryos as a model system. Our studies showed that feedbacks between cell fate, polarity and cell/tissue mechanics underlie the robust formation of early mouse embryos. I will discuss our recent work that presents yet another mechanism that ensures robustness in development.