Jürgen Knoblich's lab uses Drosophila and mouse genetics to
identify the molecular mechanisms that control asymmetric cell
division in stem cell lineages. During the past years, the lab has
identified many of the key players that regulate this process in
Drosophila neural stem cell lineages. They found that defects in
asymmetric cell division can initiate the formation of stem cell
derived tumors. More recently, Jürgen Knoblich's laboratory has
started to use genome wide loss of function analysis to
understand the control of proliferation in stem cell lineages on a
systems level.