Cytokinesis in vitro and in vivo
Date
Thursday, February 23, 2017 16:00 - 16:45
Speaker
Mohan Balasubramanian (Warwick Medical School)
Location
Experimental Biology Room (I04.2OG - LAB)
Series
Seminar/Talk
Tags
Life Sciences Seminar
Host
Carl-Philipp Heisenberg
Contact
Cytokinesis in many eukaryotes requires an actomyosin-based contractile ring. How the ring is assembled and how it generates tension are topics of active interest. We use the fission yeast Schizosaccharomyces pombe as a model to investigate these questions. We combine the methods of genetics, advanced imaging, biochemical reconstitution, biophysics, and chemistry to answer these questions. I will describe our recent work on mechanism of cytokinetic actomyosin ring contraction and disassembly focusing on the role of geometry and the molecular motor Myosin II.