Cellular drivers of injury response and regeneration in the zebrafish heart
Date
Friday, April 23, 2021 15:00 - 16:00
Speaker
Jan Philipp Junker (Max Delbrück Center, Berlin Institute for Medical Systems Biology)
Location
https://istaustria.zoom.us/j/96694528178?pwd=bnU1M09idWlLOXFZRlFIb2tWbzRxZz09
Series
Seminar/Talk
Tags
FriSBi
Host
Anna Kicheva
Contact
We recently developed LINNAEUS, a CRISPR/Cas9-based method for simultaneous transcriptome profiling and lineage tracing of thousands of single cells. Here, we use this approach to reveal principles of heart regeneration in adult zebrafish. We identify the origin and function of transient pro-regenerative cell states that are generated upon injury, and we determine mechanisms of cell type activation.