Upcoming Talks

Ista white

Neuroscience Talk Henning Sprekeler

Self-organisation in interneuron circuits

Date
Friday, September 25, 2020 15:00 - 16:00
Speaker
Henning Sprekeler (Technical University of Berlin)
Location
Online
Series
Seminar/Talk
Tags
Neurotheory Forum
Host
Tim Vogels
Contact
IST Austria / University of Oxford
Url

Inhibitory interneurons come in different classes and form intricate circuits. While our knowledge of these circuits has advanced substantially over the last decades, it is not fully understood how the structure of these circuits relates to their function. I will present some of our recent attempts to “understand” the structure of interneuron circuits by means of computational modeling. Surprisingly (at least for us), we found that prominent features of inhibitory circuitry can be accounted for by an optimisation for excitation-inhibition (E/I) balance. In particular, we find that such an optimisation generates networks that resemble mouse V1 in terms of the structure of synaptic efficacies between principal cells and parvalbumin-positive interneurons. Moreover, an optimisation for E/I balance across neuronal compartments promotes a functional diversification of interneurons into two classes that resemble parvalbumin and somatostatin-positive interneurons. Time permitting, I may briefly touch on recent work in which we link E/I balance to prediction error coding in V1. (Henning Sprekeler for Owen Mackwood, Laura Bella Naumann, Joram Keijser & Loreen Hertäg)


Qr image
Register Here
Download ICS Download invitation
Back to eventlist