The role of inositol phosphates in retrovirus assembly
Date
Thursday, April 26, 2018 14:00 - 15:00
Speaker
Robert Dick (Cornell University)
Location
Meeting room 2nd floor / Bertalanffy Bldg. (I04.2OG - LAB)
Series
Seminar/Talk
Tags
Life Sciences Seminar
Host
Florian Schur
Contact
Assembly of infectious HIV virus particles is dependent on the formation of a viral protein shell. This shell is composed of a lattice of protein hexamers. I will present recent findings that the small cellular molecule inositol hexakisphosphate (IP6) promotes lattice formation by binding to a pocket at the protein hexamer interface. This is the first small molecule identified as an HIV assembly factor.