BEGIN:VCALENDAR VERSION:2.0 PRODID:icalendar-ruby CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VTIMEZONE TZID:Europe/Vienna BEGIN:DAYLIGHT DTSTART:20260329T030000 TZOFFSETFROM:+0100 TZOFFSETTO:+0200 RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3 TZNAME:CEST END:DAYLIGHT BEGIN:STANDARD DTSTART:20261025T020000 TZOFFSETFROM:+0200 TZOFFSETTO:+0100 RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10 TZNAME:CET END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTAMP:20260825T182645Z UID:1789983000@ist.ac.at DTSTART:20260921T113000 DTEND:20260921T123000 DESCRIPTION:Speaker: Lena Schwarz & Jiawei Bao\nhosted by Jorryt Matthee & Martin Hetzer\nAbstract: Lena Schwarz | Mapping Developmental Dynamics of Autism Spectrum DisorderMouse Models at Single-Cell ResolutionAutism spect rum disorder (ASD) is associated with a wide range of risk genes\, yet how distinct mutations lead to overlapping clinical features remains poorly u nderstood. ASD is also diagnosed more often in males than females\, but th e molecular basis of this sex disparity remains unclear.We used single-nuc leus multi-omics sequencing to simultaneously examine gene expression and chromatin accessibility in 251 samples from eleven monogenic ASD mouse mod els. The dataset included both sexes\, two brain regions\, and three devel opmental stages. Across models\, ASD-associated mutations delayed radial g lial cell progression and transiently affected neural lineage specificatio n. The strongest transcriptional alterations occurred during the perinatal period\, particularly in excitatory and inhibitory neurons. These changes included reduced expression of synaptic and ion-channel-related genes\, p otentially reflecting homeostatic adaptations. Although several molecular alterations were shared across models\, each mutation also produced a dist inct molecular signature.Convergence was most pronounced at the early post natal stage\, a putatively critical period of cortical maturation and refi nement. At later developmental stages\, the shared molecular processes  i ncreasingly diverged\, identifying the early postnatal period as a key win dow of ASD-related molecular vulnerability. We also observed marked sex-sp ecific effects\, with females frequently displaying broader transcriptiona l dysregulation and larger effect sizes than males.Overall\, our findings reveal dynamic\, developmentally regulated molecular consequences of genet ically diverse ASD-associated mutations. They identify both convergent and mutationspecific mechanisms\, emphasize the importance of sex-dependent e ffects\, and provide a comprehensive view of developmental cellular and mo lecular dynamics across models of ASD.____________________________________ ___________________________________________Jiawei Bao | The Pulsing of th e Tropical Climate SystemWeather forecasts keep us prepared for the week a head\, while climate projections warn us of long-term changes over coming decades. But what about the weeks and months in between? This middle groun d\, known as the subseasonal-to-seasonal timescale\, remains one of the mo st challenging frontiers in atmospheric science\, yet it is precisely the timescale that matters most for managing floods\, droughts\, and food secu rity. In this talk\, I will walk through how scientists predict weather a nd climate\, the tools and models involved\, and why the gap in between ha s proven so difficult to bridge. I will then introduce a newly discovered phenomenon in the tropics — the Tropics-Wide Intraseasonal Oscillation ( TWISO) — a coherent pulse that links tropical weather phenomena across t he globe\, not just within one region or system\, on timescales of weeks t o months. It looks as if the tropical climate system is pulsing together. By capturing signals that existing frameworks miss\, TWISO offers a promis ing new avenue for improving predictability in the tropics\, with potentia l benefits for communities most vulnerable to extreme weather. LOCATION:ISTA | Central Building | Raiffeisen Lecture Hall\, ISTA ORGANIZER:diana.zubcevic@ista.ac.at SUMMARY:Lena Schwarz & Jiawei Bao: ISTA PostDoc Award URL:https://talks-calendar.ista.ac.at/events/6386 END:VEVENT BEGIN:VEVENT DTSTAMP:20260825T182645Z UID:1790587800@ist.ac.at DTSTART:20260928T113000 DTEND:20260928T123000 DESCRIPTION:Speaker: Francesco Locatello\nhosted by Christoph Lampert\nAbst ract: Causality at Machine Learning Scale and ComplexityDistinguishing coi ncidence from cause-and-effect relationships is a central challenge in AI (and science): which patterns just co-occur\, and which signal causality? Statistical causality offers a rigorous framework for this question\, but it assumes clean\, low-dimensional\, structured data\, which clashes with the raw\, high-dimensional observations of machine learning applications\, including in science. In this talk\, I will present how we can now learn causal structure directly from unstructured data using deep learning\, bri dging between the modeling power of causality and the scalability properti es of machine learning. I will also highlight some cross-disciplinary coll aborations my group has built\, uniquely enabled by ISTA.  LOCATION:Raiffeisen Lecture Hall\, ISTA ORGANIZER:diana.zubcevic@ista.ac.at SUMMARY:Francesco Locatello: Tenure Talk URL:https://talks-calendar.ista.ac.at/events/6548 END:VEVENT BEGIN:VEVENT DTSTAMP:20260825T182645Z UID:1791192600@ist.ac.at DTSTART:20261005T113000 DTEND:20261005T123000 DESCRIPTION:Speaker: Friedrich Stricker & Yuval Wigderson\nhosted by Mikhai l Lemeshko LOCATION:ISTA | Central Building | Raiffeisen Lecture Hall\, ISTA ORGANIZER:diana.zubcevic@ista.ac.at SUMMARY:Friedrich Stricker & Yuval Wigderson: Inaugural Lecture | Friedrich Stricker & Yuval Wigderson URL:https://talks-calendar.ista.ac.at/events/6357 END:VEVENT BEGIN:VEVENT DTSTAMP:20260825T182645Z UID:1791797400@ist.ac.at DTSTART:20261012T113000 DTEND:20261012T123000 DESCRIPTION:Speaker: Suvi Gezari Stock\nhosted by Zoltan Haiman LOCATION:Raiffeisen Lecture Hall\, ISTA ORGANIZER:diana.zubcevic@ista.ac.at SUMMARY:Suvi Gezari Stock: Institute Colloquium | Suvi Gezari Stock URL:https://talks-calendar.ista.ac.at/events/6590 END:VEVENT BEGIN:VEVENT DTSTAMP:20260825T182645Z UID:1794220200@ist.ac.at DTSTART:20261109T113000 DTEND:20261109T123000 DESCRIPTION:Speaker: Lauren O'Connell\nhosted by Lora Sweeney\nAbstract: Ti tle | Lessons from Poison Frogs on Ecological Tuning of Animal Behavior a nd PhysiologyAbstract |Behavior and physiology are the substrates of natu ral selection. Our overarching goal is to understand how new traits in phy siology and social behavior have evolved from existing genetic and cellula r components using poison frogs as research organisms. First\, we want to understand how organisms evolve ways to evade predation by using natural p roducts that target the nervous system. Animals with a rich diversity of c hemical defenses must also protect their own nervous systems from toxicity . We recently discovered toxin sponge proteins that bind deadly toxins and transport them to specific locations in poison frogs. Such a system is ri pe for reverse engineering drug carriers to better understand how chemical defenses evolve. Second\, we want to understand how new social behaviors evolve through changes in nervous system function using a comparative\, or ganismal approach. We have established poison frog tadpoles as a model sys tem for infant social behavior\, where species have evolved new communicat ion and social behaviors based on their rearing environments. Together\, t hese research avenues are enabling us to understand the design principles of chemical defense and social behaviors. LOCATION:Raiffeisen Lecture Hall\, ISTA ORGANIZER:diana.zubcevic@ista.ac.at SUMMARY:Lauren O'Connell: Lessons from Poison Frogs on Ecological Tuning of Animal Behavior and Physiology URL:https://talks-calendar.ista.ac.at/events/6550 END:VEVENT BEGIN:VEVENT DTSTAMP:20260825T182645Z UID:1794825000@ist.ac.at DTSTART:20261116T113000 DTEND:20261116T123000 DESCRIPTION:Speaker: Vivian Kuperberg & Carla Fernandez-Rico\nhosted by Mik hail Lemeshko LOCATION:ISTA | Central Building | Raiffeisen Lecture Hall\, ISTA ORGANIZER:diana.zubcevic@ista.ac.at SUMMARY:Vivian Kuperberg & Carla Fernandez-Rico: Inaugural Lecture | Vivian Kuperberg & Carla Fernandez-Rico URL:https://talks-calendar.ista.ac.at/events/6389 END:VEVENT BEGIN:VEVENT DTSTAMP:20260825T182645Z UID:1796639400@ist.ac.at DTSTART:20261207T113000 DTEND:20261207T123000 DESCRIPTION:Speaker: Daniel Robert\nhosted by Scott Waitukaitis LOCATION:Raiffeisen Lecture Hall\, ISTA ORGANIZER:diana.zubcevic@ista.ac.at SUMMARY:Daniel Robert: Institute Colloquium | Daniel Robert URL:https://talks-calendar.ista.ac.at/events/6551 END:VEVENT BEGIN:VEVENT DTSTAMP:20260825T182645Z UID:1797244200@ist.ac.at DTSTART:20261214T113000 DTEND:20261214T123000 DESCRIPTION:Speaker: Monika Visan & Simone Fatichi LOCATION:Raiffeisen Lecture Hall\, ISTA ORGANIZER:diana.zubcevic@ista.ac.at SUMMARY:Monika Visan & Simone Fatichi: Inaugural Lecture | Monika Visan & S imone Fatichi URL:https://talks-calendar.ista.ac.at/events/6552 END:VEVENT BEGIN:VEVENT DTSTAMP:20260825T182645Z UID:1800268200@ist.ac.at DTSTART:20270118T113000 DTEND:20270118T123000 DESCRIPTION:Speaker: Lora Sweeney\nhosted by Mario de Bono LOCATION:ISTA | Central Building | Raiffeisen Lecture Hall\, ISTA ORGANIZER:diana.zubcevic@ista.ac.at SUMMARY:Lora Sweeney: Tenure Talk | Lora Sweeney URL:https://talks-calendar.ista.ac.at/events/6387 END:VEVENT END:VCALENDAR