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DTSTART:20180325T030000
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DTSTART:20171029T020000
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DTSTAMP:20260409T121518Z
UID:1515492000@ist.ac.at
DTSTART:20180109T110000
DTEND:20180109T120000
DESCRIPTION:Speaker: Martin Hetzer\nhosted by Michael Sixt\nAbstract: Most 
 neurons remain in a non-diving state over an animal’s lifetime. A 
 subset of neuronal proteins persist throughout adulthood exhibiting a
 ge-dependent decline. It is unclear if extreme longevity of cells and pr
 oteins affects aging of other organs. We discovered cells and proteins 
 with exceptional lifespans in rodent brain\, liver and pancreas. Beside
 s neurons\, major cell types such as endothelial cells\, hepatocytes and
  major pancreatic cells are mostly as old as the organism. Using nucl
 ear pore complexes (NPCs) as a paradigm for long-term protein persistence\
 , we describe two distinct NPC maintenance mechanisms in quiescent and
  post-mitotic cells: NPC removal from intact nuclei and piecemeal replace
 ment\, respectively. Strikingly\, human beta cells exhibit age-dependent
  loss of NPC components and defects in nuclear integrity similar to o
 ld neurons. Our findings link long-lived cells and proteins to the
  aging process and reveal age mosaicism as a principle of adult tissue
  and protein homeostasis.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Martin Hetzer: Cell and protein age mosaicism as a fundamental orga
 nization principle of adult tissue homeostasis
URL:https://talks-calendar.ista.ac.at/events/998
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