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DTSTART:20171029T020000
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DTSTAMP:20260424T102056Z
UID:59b93eb170d68048539641@ist.ac.at
DTSTART:20171204T103000
DTEND:20171204T120000
DESCRIPTION:Speaker: Ramakanth Neeli-Venkata\nhosted by Martin Loose\nAbstr
 act: Cellular aging is an inevitable process prevalent across both unicell
 ular and multicellular organisms. The bacterium Escherichia coli serves as
  a model to study the process of aging in vivo. One cause of aging in thes
 e organisms is the accumulation of protein aggregates within the cells res
 ulting in decreased metabolic and reproductive capabilities. Recent eviden
 ces have shown that the protein aggregates\, formed as a result of environ
 mental stress or errors in protein homeostasis\, are generally sequestered
  into inclusion bodies (IBs) that get localized at the cell poles. However
 \, the underlying mechanisms that contribute to the segregation and prefer
 ential polar localization of these protein aggregates were still unknown. 
 To address this\, using Escherichia coli as our model organism\, we invest
 igated and validated our hypothesis that the presence of the nucleoid at t
 he mid-cell is responsible for the organisms ability to exclude protein ag
 gregates to the cell poles. We referred to this phenomenon as nucleoid exc
 lusion that propels the protein aggregates to become located at the cell p
 oles. Combined with multiple symmetric division events\, this results in t
 he formation of renewed cells void of protein aggregates\, thus perpetuati
 ng the cell lineages. We have further characterized the robustness of this
  nucleoid exclusion mechanism to external perturbations and stressful envi
 ronmental conditions. Overall\, our results conclude that the presence of 
 nucleoid at the mid-cell\, due to its higher density than cytoplasm contri
 butes to the polar segregation of protein aggregates inside the cell. Our 
 studies provide new and relevant mechanistic insights about the role of nu
 cleoid as a spatial organizer of protein aggregates and its contribution t
 o cellular aging mechanisms in E. coli.
LOCATION:Meeting room 3rd floor / Lab Bldg East (I06.03.211)\, ISTA
ORGANIZER:mloose@ist.ac.at
SUMMARY:Ramakanth Neeli-Venkata: Nucleoid Exclusion contributes to the immo
 rtality of E. coli cell lineages
URL:https://talks-calendar.ista.ac.at/events/981
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