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DTSTART:20171029T020000
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DTSTAMP:20260425T060428Z
UID:5a17eda81f872898062272@ist.ac.at
DTSTART:20171130T150000
DTEND:20171130T160000
DESCRIPTION:Speaker: Alma Dal Co\nhosted by Gasper Tkacik\nAbstract: Microb
 ial communities play an important role in many processes on our planet\,fr
 om the cycling of elements on Earth to human health and disease.Understand
 ing the development and dynamics of microbial communities is thusan import
 ant goal. Most interactions inside microbial communities are local: somere
 quire direct contact between cells\, while others are mediated by diffusio
 n ofcompounds through the environment. The growth and survival of an indiv
 idualcell is thus influenced by the identity and activity of other cells t
 hat live nearby.This raises the question of how different cell types arran
 ge in space. Do theyattain an arrangement that promotes beneficial cell-ce
 ll interaction and maximizesgrowth of the community? Can this arrangement 
 be maintained in time as thecommunity grows and develops?We investigate su
 ch questions with simple synthetic microbial communities. Wes t u d y a mu
 tualistic consortium of two interacting species and we investigate howthe 
 two species organize in space and how this spatial organization determines
 how well the community as a whole can grow. Using a combination of microfl
 uidicsand time-lapse microscopy\, we follow the development of the communi
 ty in timeand in a controlled environment. We observe the community at a s
 patial resolutionthat allows to measure both the growth of the individuals
  and of the community asa whole\, and for this measurements we develop spe
 cialized image analysissoftware. We established that the growth of an indi
 vidual depends on who itsneighbours are\, and that interestingly the two s
 pecies interacts with a differentnumber of neighbours. We also find that t
 he growth of the community depends onthe arrangement of the two species in
  space. To understand how the localproperties of individuals translate int
 o the global properties of the community\,we combine experiments with indi
 vidual-based modeling.Our work contributes to understanding how properties
  of biological communitiesemerge from the individual components and their 
 interactions. Natural microbialcommunities are incredibly diverse in terms
  of number of different organismsand interactions and understanding their 
 functioning is a problem ofextraordinary difficulty. We tackle this proble
 m using bottom-up research thataims at identifying basic principles in sim
 pler experimental set-ups.
LOCATION:Mondi Seminar Room 1\, Central Building\, ISTA
ORGANIZER:abonvent@ist.ac.at
SUMMARY:Alma Dal Co: Spatial organization and performance of microbial comm
 unities
URL:https://talks-calendar.ista.ac.at/events/973
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