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DTSTART:20171029T020000
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BEGIN:VEVENT
DTSTAMP:20260424T063046Z
UID:5a16e1dbc2c99432801573@ist.ac.at
DTSTART:20171205T140000
DTEND:20171205T150000
DESCRIPTION:Speaker: Raul Andino\nhosted by Daria Siekhaus\nAbstract: We ex
 amine antiviral immunity in insects. Insect transmission of arboviruses ca
 uses widespread and debilitating disease across the globe. Viral replicati
 on and dissemination in the vector are critical factors in transmission co
 mpetence. RNA interference is the insect major antiviral system that inhib
 its viral replication and viral dissemination throughout the insect tissue
 s. Using Drosophila melanogaster and mosquito Aedes aegypti experimental s
 ystems\, we discovered that immunity involves uptake of viral double stran
 ded RNA by haemocytes\, followed by reverse transcription to generate vira
 l DNAs (vDNAs) that enables amplification of the RNAi response by de novo 
 synthesis of siRNAs. This process constitutes a bona fide form of adaptive
  immunity\, which confers immunological memory in the form of stable vDNA.
  Central to immunity are macrophage-like cells\, haemocytes\, which are re
 sponsible for antiviral RNAi amplification by the production of 5-triphosp
 horylated secondary vsRNAs\, that increases the pool of vsRNAs that can be
  packaged into exosome-like vesicles (ELVs). Haemocyte-derived ELVs mediat
 e the delivery of antiviral vsRNAs to uninfected tissues and protect flies
  from infection at distal site and a systemic level. In striking parallel 
 to vertebrates\, flies also rely on systemic immunity\, albeit in this cas
 e the virus-specific signal is dsRNA-based. We hypothesize that haemocytes
  take up dsRNA from infected cells to direct the synthesis of vDNA\, which
  in turn templates secondary vsRNA providing adaptive immunity.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:amally@ist.ac.at
SUMMARY:Raul Andino: Acquired immunity in insects: systemic spread\, self/n
 onself discrimination and memory
URL:https://talks-calendar.ista.ac.at/events/972
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