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DTSTART:20180325T030000
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DTSTAMP:20260404T132950Z
UID:5a0179d06d907116099297@ist.ac.at
DTSTART:20180424T130000
DTEND:20180424T140000
DESCRIPTION:Speaker: Igor Adameyko\nhosted by Ani Kicheva\nAbstract: Lately
 \, single cell transcriptomics methods bloomed and enabled a new approach 
 to classify the cell types as well as to analyze developmental transitions
 . We took advantage of single cell transcriptomics to resolve neural crest
  heterogeneity and fate choice mechanisms. The results of our analysis sho
 wed that fate switches operate as sequential bifurcations of choices\, and
  that prior to the fate selection\, fate-specific gene clusters are hetero
 geneously activated in the early delaminating and migrating neural crest p
 opulations. Indeed\, neural crest cells show the existence of active and p
 assive differentiation-related biases operating at the gene expression lev
 el.Neural crest cells are transient embryonic progenitors that are often c
 alled 4th germ layer since they give rise to a large number of differentia
 ted cell types in the body. Thus\, neural crest is a perfect model system 
 to address the molecular mechanisms of a fate selection in case of several
  fate options. Cranial and trunk neural crest cells are different in terms
  of their competence: only cranial crest gives rise to ectomesenchymal fat
 es that include cartilage and bone. We took advantage of a single cell tra
 nscriptomics (SCT) approach to address fate selection in the neural crest.
  For this we developed a new tool for multiple differentiation trajectory 
 analysis to investigate the positons of fate splits and molecular mechanic
 s behind fate choice. The results of our analysis showed that fate switche
 s operate as sequential bifurcations of choices\, and that prior to the fa
 te selection\, fate-specific gene clusters are heterogeneously activated i
 n the early delaminating and migrating neural crest populations. These ear
 ly fate-specific genes represent weak biases that still may assist eventua
 l fate restrictions. Major biases differ between trunk and cranial crest: 
 sensory neurogenesis bias dominates trunk crest while strong mesenchymal b
 ias is present in the cranial crest. Finally\, we provide a unique gene ex
 pression signatures and gene regulatory network transitions for every neur
 al crest subpopulation along the developmental timeline and spatial distri
 bution.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:akicheva@ist.ac.at
SUMMARY:Igor Adameyko: Single cell transcriptomics of neural crest and dors
 al neural tube reveals mechanisms of fate acquisition
URL:https://talks-calendar.ista.ac.at/events/944
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