BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20180325T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20171029T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260428T211922Z
UID:5a005df7466ba913926152@ist.ac.at
DTSTART:20171113T110000
DTEND:20171113T120000
DESCRIPTION:Speaker: Oscar Ocana\nhosted by Carl-Philipp Heisenberg\nAbstra
 ct: The establishment of a left-right asymmetric pathway is a central even
 t during embryo development for proper positioning\, morphogenesis and fun
 ction of internal organs. In vertebrates\, activation of Nodal-Pitx2 axis 
 specifically within the left lateral plate mesoderm confers left identity 
 during organ positioning and differentiation. The epithelial-mesenchymal t
 ransition (EMT) inducer Snail1 represses Pitx2 on the right. Whether in ad
 dition to the repression of the left cascade an informative right-derived 
 information operates in the embryo has remained elusive. Here we show that
  in zebrafish\, BMP signaling activates another EMT inducer\, Prrx1a\, pre
 ferentially on the right that promote differential L/R cell movements and 
 heart looping through an actomyosin-dependent mechanism. Downregulation of
  Prrx1a prevents heart looping leading to mesocardia\, one of the most sev
 ere congenital heart defects. This indicates that a right-handed informati
 ve cascade also exists in vertebrates and therefore\, that two parallel an
 d mutually repressed left and right pathways\, respectively driven by Noda
 l and BMP integrate left and right information to govern the morphogenesis
  and positioning of the heart. This mechanism is conserved in the chicken 
 embryo\, and in the mouse SNAIL1 acts in a similar manner to Prrx1a in zeb
 rafish and PRRX1 in the chick. Thus\, a differential L/R EMT produces asym
 metric cell movements and forces\, more prominent from the right\, that dr
 ive heart laterality in vertebrates.
LOCATION:Meeting room 2nd floor / Bertalanffy Bldg. (I04.2OG - LAB)\, ISTA
ORGANIZER:lalesch@ist.ac.at
SUMMARY:Oscar Ocana: A Left-Right differential cell migration drives heart 
 looping in vertebrates
URL:https://talks-calendar.ista.ac.at/events/943
END:VEVENT
END:VCALENDAR