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BEGIN:VEVENT
DTSTAMP:20260427T100806Z
UID:1510920000@ist.ac.at
DTSTART:20171117T130000
DTEND:20171117T140000
DESCRIPTION:Speaker: Balazs Enyedi\nhosted by Carl-Philipp Heisenberg\nAbst
 ract: Inflammatory signals have long been known to arise upon cell lysis a
 nd necrosis during tissue damage. Recently we have shown that epithelial d
 amage detection is also mediated by direct surveillance of barrier integri
 ty. In zebrafish larvae\, osmotic cues from the environment cause cell swe
 lling at the wound margin\, which leads to rapid leukocyte recruitment thr
 ough the activation of cytosolic phospholipase A2 (cPLA2). Arachidonic aci
 d released by cPLA2 is oxidized to pro-inflammatory eicosanoids by 5-lipox
 ygenase (5-LOX) on the nuclear envelope. Osmotic cell swelling activates c
 PLA2 by translocating it from the nucleoplasm to the nuclear envelope. Ele
 vated cytosolic Ca2+ is necessary but not sufficient for cPLA2 translocati
 on\, and we now show that nuclear swelling is required as a parallel input
 . F-actin limits nuclear swelling and cPLA2 translocation during cell swel
 ling. cPLA2 translocation upon nuclear swelling was reconstituted in isola
 ted nuclei\, and appears to be a simple physical process mediated by tensi
 on in the nuclear envelope. Our data show that the cell nucleus serves an 
 unexpected role as the primary mechanosensor for transduction of cell swel
 ling and lysis into pro-inflammatory eicosanoid signaling. Cell swelling a
 nd lysis are widely implicated in inflammatory pathology. We propose that 
 the nucleus plays a general mechanosensory role in inflammation\, and this
  explains why cPLA2 and 5-LOX localize to nuclei in many tissues.
LOCATION:Mondi 1\, ISTA
ORGANIZER:Zoltan Spiro
SUMMARY:Balazs Enyedi: From tissue damage to nuclear swelling: a novel mech
 anism of epithelial wound detection
URL:https://talks-calendar.ista.ac.at/events/940
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