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DTSTART:20180325T030000
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DTSTART:20171029T020000
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DTSTAMP:20260427T115930Z
UID:59ccf10bd0421370703352@ist.ac.at
DTSTART:20171107T130000
DTEND:20171107T140000
DESCRIPTION:Speaker: Noelia Urban Avellaneda\nhosted by Simon Hippenmeyer\n
 Abstract: Ascl1 is a proneural transcription factor with important functio
 ns during brain development and adult neurogenesis. Overexpression of Ascl
 1 in neural stem cells rapidly induces cell cycle exit and differentiation
 . However\, Ascl1 is also crucial for the proliferation of neural progenit
 ors. We have previously shown that Ascl1 stability is regulated by the E3-
 ubiquitin ligase Huwe1. We demonstrated that adult hippocampal stem cells 
 rely on Huwe1-dependent degradation of Ascl1 to exit the cell cycle and re
 turn to quiescence. This allowed us to show the importance of the return t
 o quiescence of adult neural stem cells for the long-term maintenance of n
 eurogenesis.Since Ascl1 is essential for the development of the ventral te
 lencephalon\, we are now analysing the effects of Huwe1 deletion at embryo
 nic stages. Our results show that Ascl1 protein is highly increased in the
  brains of Huwe1 mutant mice. We observe that Ascl1 stabilisation not only
  does not promote neuronal differentiation but also impairs the exit from 
 the cell cycle of neural precursors\, resembling our findings in the adult
  brain.  We are currently investigating the mechanisms behind the seemingl
 y counterintuitive pro-proliferative effect of Ascl1 stabilisation. Overal
 l\, our findings will help understand how key factors in stem cell biology
 \, such as Ascl1 for neural stem cells\, can exert a great diversity of fu
 nctions in a context-dependent manner.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Noelia Urban Avellaneda: Post-transcriptional regulation of embryon
 ic and adult neurogenesis.
URL:https://talks-calendar.ista.ac.at/events/931
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