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DTSTART:20171029T020000
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DTSTAMP:20260427T234117Z
UID:59f029928f508002565406@ist.ac.at
DTSTART:20171030T150000
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DESCRIPTION:Speaker: Philipp Velicky\nhosted by Johann Georg Danzl\nAbstrac
 t: Trophoblast cells arise from the very first lineage specification in ea
 rly mammalian development and form the trophectoderm\, which gives rise to
  the extra-embryonic placenta. Different trophoblast subpopulations consti
 tute a selective barrier between mother and embryo and are responsible for
  nutrient and oxygen uptake of the developing offspring and the production
  of pregnancy maintaining hormones. Despite their pivotal role\, comparati
 vely little is known about the biology of human trophoblasts.During the pa
 st three years our team focused on the cell cycle status of trophoblasts d
 uring their differentiation from epithelial cells to highly invasive mesen
 chymal cell. Using multiple cytometric and imaging techniques we found\, i
 n contrast to the scientific consensus\, evidence for extensive endoredupl
 ication and polyploidization\, a process where a cell duplicates its genom
 e without subsequent cell division.  In a second project we investigated t
 he expression of the histamine-degrading enzyme diamine oxidase in the mat
 ernal-foetal interface. Contrary to published literature we revealed that 
 diamine oxidase does not originate from maternal uterine cells but that it
  is exclusively expressed and secreted by a specific subset of placenta-de
 rived trophoblast cells. Since these cells are suspected to be affected in
  the severe pregnancy disorder preeclampsia we hypothesized that diamine o
 xidase might serve as biomarker to predict an emerging disease. In a colla
 borative effort with the Department of Pharmacology of the Medical Univers
 ity of Vienna and the Harvard Medical School we could confirm our hypothes
 is by revealing significant differences between healthy women and those wh
 o developed preeclampsia later on during pregnancy.
LOCATION:Meeting room 1st floor  / Lab Bldg East (I06.01.406)\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Philipp Velicky: Everything you always wanted to know about trophob
 lasts* (*including the answer to:  what is a trophoblast?)
URL:https://talks-calendar.ista.ac.at/events/894
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