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DTSTART:20180325T030000
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DTSTART:20171029T020000
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DTSTAMP:20260428T211927Z
UID:59d7450bb24da147549107@ist.ac.at
DTSTART:20171031T140000
DTEND:20171031T150000
DESCRIPTION:Speaker: Luis García-Rabaneda\nhosted by Gaia Novarino\nAbstra
 ct: Mood and anxiety disorders are characterized by a persistent or dispro
 portionate state of alarm that interferes with normal life\, and affect mo
 re than 20% of the European population.  Despite their prevalence\, no rat
 ionale-based therapies are currently available. One important clue to iden
 tify new therapeutic targets is the comorbidity among different psychiatri
 c disorders. For example\, the circuits involved in substance abuse and ad
 diction largely overlap with the ones thought to underlie anxiety. Of inte
 rest in this context are the non-conventional GluN3A subunits of NMDA-type
  glutamate receptors (NMDARS) which are highly expressed during critical p
 eriods of postnatal development. GluN3A subunits are principal modulators 
 of network rewiring by early experience\, which is known to shape adult em
 otional and affective behaviors\, and mutations in GRIN3A (the gene encodi
 ng GluN3A) have been linked to nicotine\, alcohol and cocaine addiction in
  adult individuals.To address whether altered GluN3A expression could modu
 late anxiety responses\, we conducted a battery of behavioral tasks testin
 g anxiety and depression in knockout mice lacking GluN3A (GluN3A KO) and t
 ransgenic mice that overexpress GluN3A beyond its physiological time windo
 w (GFP-GluN3A dt). Our analysis revealed a robust anxiolytic-like phenotyp
 e of adult mice that lack GluN3A expression (GluN3A KO). We further explor
 ed the consequences of altered GluN3A expression on the emotional and depr
 essive features to sub-chronic stress and found that GluN3A KO mice are re
 markably resilient to sub-chronic stress. Our results reveal putative new 
 molecular targets to treat neurological disorders associated with depressi
 on and anxiety.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Luis García-Rabaneda: UNDERSTANDING MOOD DISORDERS: AN EMERGING RO
 LE FOR GLUN3A NMDAR SUBUNITS.
URL:https://talks-calendar.ista.ac.at/events/877
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