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DTSTART:20170326T030000
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DTSTART:20171029T020000
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BEGIN:VEVENT
DTSTAMP:20260427T194927Z
UID:59b7efe951991418523345@ist.ac.at
DTSTART:20170925T110000
DTEND:20170925T120000
DESCRIPTION:Speaker: Freyja Ólafsdóttir\nhosted by Jozsef Csicsvari\nAbst
 ract: Reactivations of hippocampal place cell sequences (replay) during be
 havioural immobility and rest have been linked with both memory consolidat
 ion and navigational planning. Yet\, it remains to be investigated whether
  these functions are temporally segregated. We recorded\, concurrently\, C
 A1 place cells and grid cells from the deeper layers of the media entorhin
 al cortex (MEC V/VI) in 8 rats while animals carried out a self-paced spat
 ial task and during a subsequent rest session.  We observed that immediate
 ly before movement onset towards a reward location\, or just after arrival
  at a reward location\, hippocampal replay was task-focused\; preferential
 ly expressing places and trajectories consistent with the animals directio
 n of travel. In contrast\, during extended stops at reward locations\, no 
 such biases were evident. Importantly\, the occurrence of task-focused rep
 lay predicted the accuracy of subsequent spatial decisions. Further\, duri
 ng extended immobility\, but not during periods preceding or succeeding mo
 vement\, we observed MEC (V/VI) grid cells were coherent with hippocampal 
 replay.  During the subsequent rest session we\, similarly\, observed grid
 -place cell replay coherence and found it was accentuated for replay seque
 nces recapitulating the order in which cells fired during behaviour (forwa
 rd replay) but that the grid cells lagged the place cells by ~11ms. Thus\,
  hippocampal replay may dynamically and abruptly switch operational mode i
 n response to task demands and behavioural state\; plausibly reflecting a 
 functional switch between planning and memory consolidation.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Freyja Ólafsdóttir: Replay is Dynamically Influenced by Task Dema
 nds and Behavioural State
URL:https://talks-calendar.ista.ac.at/events/825
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