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DTSTART:20170326T030000
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DTSTAMP:20260427T120036Z
UID:59b7f2f076e89715244243@ist.ac.at
DTSTART:20170920T110000
DTEND:20170920T120000
DESCRIPTION:Speaker: Michael Krieg\nhosted by Carl-Philipp Heisenberg\nAbst
 ract: All animals and plants\, even protozoa\, have evolved specialized mo
 lecular sensors that convert mechanical stress into behavioral responses. 
 The touch receptor neurons (TRNs) in Caenorhabditis elegans respond to gen
 tle body touch and are especially well characterized on a physiological an
 d ultrastructural level\, a knowledge which is unavailable in other animal
 s. Moreover\, C. elegans is a unique model organism to study the mechanics
  of neurons due to their simple shapes\, the known wiring diagram and a ri
 ch repertoire of simple behaviors\, thus permitting a systems perspective 
 on cell function. As in other animals\, neuron morphology is critical for 
 function in C. elegans. Some neurons are highly branched and curved\, whil
 e others are extremely straight. How the constituent molecules of these di
 fferent neurons establish a functional organization and how nanometer size
 d molecules can determine cell shape in the millimeter scale is still not 
 understood. To establish this paradigm\, we first analysed different mutan
 t neurons defective in spectrin and tau cytoskeleton\, which undergo refor
 mations highly reminiscent of a twisted\, elastic thread under compression
  and modeled their shapes using a discrete elastic rod modelborrowed from 
 differential geometry. We then used electron\, STED and force-FRET microsc
 opy in conjunction with mechanical measurements to test the predictions fr
 om the model and found that a balance of axial tension\, bending rigidity 
 and mechanical torque ensures that long slender axons comply smoothly unde
 r external stresses. At the end Ihighlight\, how these mechanical paramete
 rs influence neuronal function during the sense of touch.
LOCATION:Meeting room 1st floor / Central Bldg. (I01.1OG - Zentralgebäude)
 \, ISTA
ORGANIZER:lalesch@ist.ac.at
SUMMARY:Michael Krieg: The mechanical control of neuron shape and function
URL:https://talks-calendar.ista.ac.at/events/824
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