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TZID:Europe/Vienna
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DTSTART:20170326T030000
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DTSTART:20171029T020000
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BEGIN:VEVENT
DTSTAMP:20260427T194928Z
UID:5996e19cacd4d809176516@ist.ac.at
DTSTART:20170921T170000
DTEND:20170921T180000
DESCRIPTION:Speaker: Francesco Tombola\nhosted by Harald Janovjak\nAbstract
 : Voltage-gated proton channels (Hvs) are expressed in tissues throughout 
 the body and play important roles in pH homeostasis and in the regulation 
 of NOX enzymes. They consist of two proton-permeable voltage-sensing domai
 ns linked together by a cytoplasmic coiled-coil domain. Their voltage-depe
 ndent activation is affected by a variety of stimuli\, including transmemb
 rane pH gradients\, mechanical force\, and temperature. Excessive proton c
 hannel activity has pathological consequences\, such as increased invasive
 ness in cancer\, and enhanced brain damage in ischemic stroke. In this pre
 sentation\, I will discuss the physiological and pathological functions of
  Hv channels\, as well as our efforts to elucidate their mechanism of acti
 vation and to develop small-molecule inhibitors that could find applicatio
 ns as anticancer drugs and neuroprotective agents.\n\nIn cooperation with
  \n
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:amally@ist.ac.at
SUMMARY:Francesco Tombola: Voltage-gated proton channels: "When too much of
  a good thing is a disease"
URL:https://talks-calendar.ista.ac.at/events/793
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