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DTSTART:20170326T030000
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DTSTART:20171029T020000
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DTSTAMP:20260427T115852Z
UID:599ae9d5b8561844717003@ist.ac.at
DTSTART:20170905T100000
DTEND:20170905T110000
DESCRIPTION:Speaker: Eckhard Lammert\nhosted by Carl-Philipp Heisenberg\nAb
 stract: The lymphatic vasculature is key for immunity and fluid transport 
 within any given mammalian organism. We have previously shown that this va
 sculature grows in size whenever fluid accumulates within a tissue. The ex
 panded lymphatic vasculature subsequently helps to drain the interstitial 
 fluid and brings it back to the blood vasculature\, thus providing edema w
 ithin a tissue. beta1-integrin is required for sensing an increased fluid 
 pressure and for trans-activating VEGFR3\, which triggers proliferation of
  the lymphatic endothelial cells and growth of the lymphatic vasculature. 
 We now show that integrin-linked kinase (ILK) acts as a gatekeeper to prev
 ent too much lymphatic growth upon fluid accumulation. We also show that t
 he small vessels of the liver\, the only fully regenerating inner organ in
  mammals\, behave similar to the lymphatic vessels in that they increase t
 heir VEGFR3 activation in a beta1-integrin dependent manner when mechanica
 lly stimulated in vitro and in vivo. We provide evidence that an increased
  blood flow through the liver activates this mechanotransduction pathway a
 nd triggers release of signals from the liver sinusoidal endothelial cells
  to drive hepatocyte proliferation and liver growth. This scenario helps t
 o explain why the liver starts to regenerate and “knows” when to stop gr
 owing. Our studies were performed in embryonic and adult mice\, using gene
 tic and physiologic manipulations\, and are supplemented with data from hu
 man cells and human individuals. They contribute to better understanding g
 rowth and regeneration of tissues in mammals and humans.
LOCATION:Meeting room 2nd floor / Bertalanffy Bldg. (I04.2OG - LAB)\, ISTA
ORGANIZER:lalesch@ist.ac.at
SUMMARY:Eckhard Lammert: Mechanical forces in organ growth and regeneration
URL:https://talks-calendar.ista.ac.at/events/792
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