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DTSTART:20170326T030000
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DTSTART:20171029T020000
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DTSTAMP:20260427T114705Z
UID:599acd9267f7c113320417@ist.ac.at
DTSTART:20170920T140000
DTEND:20170920T150000
DESCRIPTION:Speaker: Nathan W. Goehring\nhosted by Martin Loose\nAbstract: 
 The conserved PAR polarity network drives cell polarity in a wide range of
  contexts\, from asymmetric cell division and fate specification to epithe
 lial and neural architecture. At its core is a set of conserved feedback p
 athways that segregate two sets of opposing PAR proteins into defined memb
 rane domains that specify the axis of polarity and spatially regulate down
 stream pathways. We currently are working to define the basic principles o
 f this intracellular patterning system that underlies its ability to robus
 tly polarize cells in response to developmental cues\, using the C. elegan
 s embryo as a model system. A key question in the lab is understanding how
  polarized patterns emerge from and are defined by the interplay between t
 he individual mobilities of PAR proteins and the modification of these mob
 ilities in space and time. I will discuss recent work on functional specia
 lization between distinct forms of a conserved PAR complex that balances c
 ue sensing and effector functions of the PAR network as well as potential 
 physical constraints on PAR polarity that arise during development.
LOCATION:Mondi Seminar Room 1\, Central Building\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Nathan W. Goehring: Design Principles of the PAR Cell Polarity Netw
 ork
URL:https://talks-calendar.ista.ac.at/events/791
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