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DTSTART:20170326T030000
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DTSTAMP:20260427T100731Z
UID:5991a408cde7f131301989@ist.ac.at
DTSTART:20170828T110000
DTEND:20170828T120000
DESCRIPTION:Speaker: Oliver Thorn-Seshold\nhosted by Harald Janovjak\nAbstr
 act: Progress in biology and medicine in the 20th Century was driven by sm
 all molecule inhibitors\, that could be used to modulate protein function 
 and disfunction\, and to treat diseases. But many of the most important pr
 oteins actin\, tubulin\, topoisomerases\, proton pumps\, nuclear hormone r
 eceptors\, kinases can never be fully studied and understood using classic
 al inhibitors\, and these inhibitors are not typically suitable as clean t
 herapeutic drugs. This is because these critical proteins have many spatio
 temporally distinct functions: either simultaneously but in different plac
 es (regions/cells/tissues)\, or in the same place but at different times: 
 and some of those functions are critical for healthy cell/organism functio
 n. Downregulating or blocking all those functions in all organelles/cells/
 tissues at once\, is about as sophisticated a research method as destroyin
 g the entire Vienna road network to learn what are night buses used for in
  the Naschmarkt? Yet\, spatiotemporally-controllable inhibitors are recent
 ly becoming available\, that do allow high-precision studies\, and may als
 o enable high-precision therapy.* This talk presents a case study of photo
 pharmaceuticals for the tubulin and actin cytoskeleton that act as an opti
 cally-controlled interface between a researcher and the protein of interes
 t. They can leverage the spatiotemporal precision of standard light delive
 ry methods to achieve optogenetics-like spatiotemporal specificity of prot
 ein control\, without requiring genetic manipulation and therefore offer n
 ew opportunities for research and therapy.\n\n* Optogenetics has shown sev
 eral unique applications of high-spatiotemporal-resolution protein control
 \, relying on transgenic cells and animals. But usually\, optogenetic modi
 fications are restricted to non-critical proteins\, and there are no attem
 pts yet to use optogenetics as a therapeutic strategy for human patients.\
 n
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:amally@ist.ac.at
SUMMARY:Oliver Thorn-Seshold: Optically Controlled Inhibitors for High-Spat
 iotemporal-Resolution Studies and Therapy
URL:https://talks-calendar.ista.ac.at/events/760
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