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DTSTAMP:20260429T024213Z
UID:585bcd07c9c79013252582@ist.ac.at
DTSTART:20170130T094500
DTEND:20170130T104500
DESCRIPTION:Speaker: Benjamin Machta\nAbstract: Biological systems are imme
 nsely complicated at the molecular scale.  However\, they often display em
 ergent behavior that is rich\, but comprehensible.   I will first discuss 
 a geometric framework for quantifying this emergent simplicity\, highlight
 ing parallels to physics\, where a similar compression of microscopic deta
 ils explains the success of effective theories like the diffusion equation
 .   I will then discuss how this same geometric framework can be used to b
 ound the energetic cost of controlling a small system\, with implications 
 for the highly dissipative single molecule machines that carry out biologi
 cal function.  \n\nThe second part of my talk will focus on the plasma mem
 brane\, a two dimensional liquid that surrounds mammalian cells and which 
 is home to many of the complex processes that carry out biological informa
 tion processing.  Recent experiments have demonstrated that this membrane 
 is close to a liquid-liquid critical point\, distinguished by emergent tim
 e and length scales much larger than individual molecules.   I will talk a
 bout what this critical point means for the function of membrane bound pro
 teins\, mediating long-ranged forces\, sensitive allosteric regulation and
  non-Markovian dynamics.  I will also report on our recent experimental pr
 ogress demonstrating that anesthetics move membranes away from criticality
 \, and that anesthetic reversers also reverse effects on membrane critical
 ity.  Our results suggest a model wherein anesthetics exert their influenc
 e by interfering with membrane regulation of bound ion channels.
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:pdelreal@ist.ac.at
SUMMARY:Benjamin Machta: Ion channels\, critical points and emergent phenom
 ena in biology
URL:https://talks-calendar.ista.ac.at/events/73
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