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DTSTART:20190331T030000
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DTSTART:20191027T020000
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DTSTAMP:20260405T122200Z
UID:1558965600@ist.ac.at
DTSTART:20190527T160000
DTEND:20190527T170000
DESCRIPTION:Speaker: Josh Sanes\nhosted by Maximilian Jösch\nAbstract: Cla
 ssification of neurons was a major preoccupation of Cajal\, but later came
  to be viewed as a fairly boring enterprise.  However\, inability to defi
 ne neuronal types has now emerged as a major bottleneck in analysis of neu
 ral circuits. Recent technical advances are improving the situation. We ha
 ve applied one of them\, high throughput single cell RNAseq\, to the retin
 a\, the model system on which our research focuses. To generate a cell atl
 as\, we obtain large numbers of transcriptomes\, improve bioinformatic met
 hods for analyzing the data\, and match types defined molecularly to those
  defined by morphological and physiological criteria. The mouse retina (>1
 00\,000 cells profiled) appears to comprise around ~130 cell types and a m
 ore recently completed macaque retinal atlas (165\,000 cells) comprises ~7
 0 types. We are now beginning to use the atlases to probe retinal developm
 ent\, function and dysfunction in ways I will discuss: (1) Profiling retin
 al ganglion cells (RGCs) at earlier stages to learn how immature cells of 
 a heterogeneous class diversify into ~45 types. (2)  Analyzing RGCs follo
 wing injury (optic nerve crush) or in disease models (glaucoma) to seek ea
 rly transcriptional signatures that correlate with\, and differences in th
 e vulnerability of some RGC types to these insults. (3) Probing the evolut
 ion of cell types by profiling cells from several other vertebrates\, incl
 uding human\, marmoset\, chick\, zebrafish\, peromyscus\, pig and ferret.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Josh Sanes: Cell types as building blocks of neural circuits
URL:https://talks-calendar.ista.ac.at/events/729
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