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TZID:Europe/Vienna
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DTSTART:20190331T030000
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DTSTART:20191027T020000
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BEGIN:VEVENT
DTSTAMP:20260406T074257Z
UID:1558360800@ist.ac.at
DTSTART:20190520T160000
DTEND:20190520T170000
DESCRIPTION:Speaker: Magdalena Götz\nhosted by Simon Hippenmeyer\nAbstract
 : We study the mechanisms of neurogenesis in order to implement them for n
 euronal repair. I will present unpublished work about the molecular functi
 on of Trnp1\, a novel nuclear protein\, with key roles in promoting neural
  stem cell self-renewal and neurogenesis (Stahl et al.\, Cell 2013). This 
 shows unprecedented functions in regulating several nuclear processes by i
 ts N-terminal intrinsically disordered region which is highly conserved in
  mammals. I will then show that Trnp1 is also critical for direct neuronal
  reprogramming (Masserdotti et al.\, Cell Stem Cell 2015) and up-date on t
 he recent breakthrough in direct glia-to-neuron conversion after brain inj
 ury (Gascon et al.\, 2016\; unpublished data). I will then move on to disc
 uss the integration of replaced neurons into the circuitry of the murine c
 erebral cortex (Falkner\, Grade et al.\, Nature 2016)\, that normally does
  not integrate new neurons at adult stages and present unpublished data ab
 out the mechanisms regulating this integration. Taken together\, our knowl
 edge about basic mechanisms of neurogenesis allowed making great strides t
 owards neuronal repair.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Magdalena Götz: Novel mechanisms of neurogenesis and neural repair
URL:https://talks-calendar.ista.ac.at/events/728
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