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DTSTART:20190331T030000
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DTSTART:20191027T020000
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DTSTAMP:20260406T171932Z
UID:1557756000@ist.ac.at
DTSTART:20190513T160000
DTEND:20190513T170000
DESCRIPTION:Speaker: Leonid Sazanov\nhosted by Michael Sixt\nAbstract: Memb
 rane proteins are responsible for many fundamental cellular processes incl
 uding the transport of ions and metabolites\, energy conversion and signal
  transduction. Many of these proteins work as molecular machines\, employi
 ng large-scale motions to perform their function. We are interested in the
  structure and function of such machines\, mainly from the domain of bioen
 ergetics (i.e. biological energy conversion\, such as in respiration and p
 hotosynthesis).Respiratory chain of mitochondria and bacteria\, responsibl
 e for most of energy production in the cell\, comprises a series of such m
 achines (complexes I-V) working in concert to produce ATP (universal biolo
 gical energy carrier). Complex I is the first and the largest enzyme in th
 e chain\, coupling electron transfer between two substrates to the translo
 cation of four protons across the membrane. Previously we have determined 
 the first atomic structure of complex I\, using X-ray crystallography on b
 acterial enzyme. More recently\, after the move to IST\, we have solved th
 e first structure of the even larger (1 MDa\, 45 subunits) mammalian compl
 ex I\, using new cryoEM methods. In mitochondria respiratory complexes are
  organised into supercomplexes\, or respirasomes\, and we have solved stru
 ctures of these supercomplexes\, also using cryoEM. Current work is centre
 d on the deciphering of the enigmatic coupling mechanism of complex I and 
 on the functional role of the supercomplexes. Apart from complex I\, we ar
 e working also on other intriguing molecular machines\, such as ATPase (co
 mplex V)\, MRP antiporters and proton-translocating transhydrogenase.Each 
 of these biological machines employs unique mechanism\, resembling enginee
 ring creations\, such as turbine or steam engine. Each new structure bring
 s a lot of surprises\, showing Nature’s ingenuity in efficiently impleme
 nting different pathways necessary for life.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Leonid Sazanov: Structure and mechanism of membrane-embedded molecu
 lar machines
URL:https://talks-calendar.ista.ac.at/events/727
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