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DTSTAMP:20260405T192600Z
UID:1538402400@ist.ac.at
DTSTART:20181001T160000
DTEND:20181001T170000
DESCRIPTION:Speaker: Grant Jensen\nhosted by Florian Schur\nAbstract: In th
 e last ten years electron cryotomography has made it possible to visualize
  large macromolecular assemblies inside intact cells in a near-native\, "f
 rozen-hydrated" state in 3-D to a few nanometers resolution. Increasingly\
 , atomic models of individual proteins and smaller complexes obtained by X
 -ray crystallography\, NMR spectroscopy\, or other methods can be fit into
  cryotomograms to reveal how the various pieces work together inside cells
 . A few good pictures is therefore sometimes all that is really needed to 
 distinguish between competing models.  To illustrate these points\, I wil
 l present examples of current results from our recent work on bacterial se
 cretion systems\, including new images and mechanistic insights into type 
 II\, IV\, V\, and VI secretion systems.  The range of cellular samples th
 at ECT can reveal is dramatically expanding with FIB-milling\, and will li
 kely soon become dramatically more useful with correlated light and electr
 on microscopy (CLEM) targeting. Two major developments in ECT technology f
 urther suggest that ECT will become an important new method for determinin
 g the structures of single particles and small proteins as well. First\, h
 ighly eucentric stages are now allowing tilt-series to be recorded in seco
 nds rather than minutes\, opening the possibility of high resolution singl
 e particle tomography.  Second\, ECT of very small crystals (“nanocryst
 als”) offers compelling potential advantages over X-ray crystallography.
   I will explain these advances and their projected implications with exa
 mples from our work.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Grant Jensen: Electron cryotomography: present capabilities and fut
 ure potential
URL:https://talks-calendar.ista.ac.at/events/707
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