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DTSTART:20170326T030000
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DTSTART:20171029T020000
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DTSTAMP:20260428T233005Z
UID:59563017ee81e820318975@ist.ac.at
DTSTART:20170705T110000
DTEND:20170705T120000
DESCRIPTION:Speaker: Lukas Groschner\nhosted by Harald Janovjak\nAbstract: 
 Decisions take time because the information needed to make them is rarely 
 available all at once but must be gathered sequentially. In fruit flies di
 scriminating two odours\, the amount of time taken varies with the difficu
 lty of the comparison and is influenced by approximately 160 αβ core (α
 βc) Kenyon cells of the mushroom bodies. These neurons are distinguished 
 by the expression of FoxP\, a transcription factor whose human orthologues
  are important determinants of cognitive ability. FoxP mutants are slower 
 to commit than wild-type flies and\, in some allelic combinations\, are al
 so more error-prone.\n\nI will report on progress in characterizing the ph
 ysiology of αβc Kenyon cells and its regulation by FoxP. Specifically\, 
 I will show that these neurons integrate subthreshold depolarizations evok
 ed by individual quanta of sensory information over exceptionally long tim
 eframes\, and that the ability to do so dictates behavioural performance. 
 FoxP affects reaction times by tuning the integrative properties of αβc 
 Kenyon cells via repression of a dendritic potassium channel. I will outli
 ne a quantitative correspondence between cellular biophysics and psychophy
 sical performance that suggests a mechanistic connection between synaptic 
 integration and the accumulation of sensory information over time.
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:amally@ist.ac.at
SUMMARY:Lukas Groschner: Time to decide - how fruit flies think it over
URL:https://talks-calendar.ista.ac.at/events/674
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