BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20270328T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20261025T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20261019T104849Z
UID:1793619000@ist.ac.at
DTSTART:20261102T123000
DTEND:20261102T133000
DESCRIPTION:Speaker: Stavros Papadopoulos\nhosted by Michael Sixt\nAbstract
 : The evolution of the vertebrate limb-torso-limb body plan drove a divers
 ification of motor behavior\, with limb and non-limb regions exhibiting in
 dividual but also crosscoordinated motor repertoires. How neural circuits 
 are organized to generate distinct outputs across body regions\, however\,
  remains unknown. Amphibians\, the first tetrapods to walk on land\, trans
 ition to limb locomotion during metamorphosis and offer a unique perspecti
 ve on the underlying spinal cord transformation. They are separated from m
 ammals by almost 360 million years of evolution\, and although they share 
 a common limb-torso-limb organization\, they display unique behavioral pat
 terns along their body axis. Here\, we construct a cross-species\, spatiot
 emporal atlas of spinal interneurons spanning the rostrocaudal and develop
 mental axes of frogs and mice. We uncover a common framework of interneuro
 n regionalization that mirrors each vertebrate’s body plan and motor out
 put. We find Hoxc9 is a master regulator of both rostrocaudal neuron archi
 tecture and neurogenesis itself: subtype architecture and progenitor expan
 sion are transformed thoracic-into-brachial and brachial-into-thoracic by 
 hoxc9 mutation and Hoxc9 overexpression\, respectively. Combining electrop
 hysiology with computational modelling\, we show that changing regional ci
 rcuit architecture is sufficient to respecify motor output\, a combined pr
 oduct of motor and commissural interneurons. Together\, these findings est
 ablish a causal link between developmental patterning\, circuit architectu
 re\, and motor function\, identifying interneuron regionalization as a fun
 damental organizational principle linking bodyplan evolution to motor dive
 rsity. Our study lays a foundation to further dissect and directly relate 
 individual regional differences in neuron architecture\, such as subtype i
 dentity\, spatial organization\, and projection pattern\, to motor variati
 on. And thus\, uncovering how specific behavioral necessities are met by s
 pinal circuits along the rostrocaudal axis throughout development and acro
 ss species.
LOCATION:Sunstone Bldg / Ground floor / Big Seminar Room B (I23.EG.102) and
  Zoom\, ISTA
ORGANIZER:
SUMMARY:Stavros Papadopoulos: Thesis Defense: THE FORM-FUNCTION CONTINUUM O
 F TETRAPOD SPINAL REGIONALIZATION: Hox-Dependent Neurogenesis\, Architectu
 re and Output
URL:https://talks-calendar.ista.ac.at/events/6709
END:VEVENT
END:VCALENDAR