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DTSTAMP:20261109T161212Z
UID:1793615400@ist.ac.at
DTSTART:20261102T113000
DTEND:20261102T123000
DESCRIPTION:Speaker: Tim Clausen\nhosted by Paul Schanda\nAbstract: The Dar
 k Side of Ubiquitin: When Defence Turns into DiseaseThe ubiquitin system i
 s best known for controlling protein degradation\, but its molecular mecha
 nisms extend into unexpected and largely unexplored territory. One intrigu
 ing aspect is its ability to modify non-protein substrates and coordinate 
 cellular responses to infection and stress. How these unconventional activ
 ities are regulated and contribute to health and disease\, remains poorly 
 understood.At the heart of this non-mainstream ubiquitin biology are ZNFX1
  and RNF213\, two enigmatic members of a distinct family of ubiquitin (E3)
  ligases that challenge established concepts of how ubiquitin is used in c
 ellular defence. Combining structural biology\, biochemistry and cellular 
 approaches\, we uncovered surprising mechanisms by which these giant E3 li
 gases sense nucleic acids and changes in cellular energy levels\, translat
 ing these signals into protective responses. Our findings reveal how molec
 ular re-assembly and large-scale conformational changes control their acti
 vity\, enabling cells to respond to diverse threats while preventing inapp
 ropriate activation and ubiquitin signalling. We also discovered how disea
 se mutations can bypass the regulatory safeguards of E3 ligases\, turning 
 a protective immune mechanism into a driver of inflammation and cellular d
 amage.
LOCATION:Raiffeisen Lecture Hall\, ISTA
ORGANIZER:diana.zubcevic@ista.ac.at
SUMMARY:Tim Clausen: Institute Colloquium | Tim Clausen
URL:https://talks-calendar.ista.ac.at/events/6707
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