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DTSTART:20260329T030000
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DTSTAMP:20260819T091004Z
UID:6a6718ef86935830306549@ist.ac.at
DTSTART:20260903T134500
DTEND:20260903T150000
DESCRIPTION:Speaker: Eduardo Fernández Ortuño\nhosted by Lora Sweeney
 \nAbstract: The phenomenal size and cellular diversity of the human cerebr
 al cortex is the outcome of an elaborate developmental program sculpted by
  evolutionary forces during millions of years. This evolution involved cha
 nges in neural progenitor cells\, which compared to reptiles and birds acq
 uired the capacity to generate larger numbers of neurons and in greater di
 versity. Genetic causes of increased progenitor cell proliferation during 
 evolution have been identified\, but mechanisms involved in the diversific
 ation of neural progenitor cells remain unknown. To address this question\
 , we performed the first integrated\, multi-level\, comparative study of n
 eural progenitor cells and lineages in the embryonic cortex across amniote
 s. The analysis was focused on four strategic species that cover the spect
 rum of cortical phenotypes: house snake\, chick\, mouse and ferret. Our re
 sults revealed an unsuspected diversity of basal progenitor cell types in 
 chick\, superior to mouse and with similarities to the more complex ferret
  cortex. Chick dorsal pallial progenitors included subapical and basal Rad
 ial Glia\, and co-expressed Pax6 and Tbr2\, similar to ferret but unlike m
 ouse\, where these are largely absent. Our findings challenge current conc
 epts on the evolutionary trajectory of the cerebral cortex\, revealing a v
 ery early diversification of cortical progenitor cell types in amniotes th
 at predated the last common ancestor of mammals and birds.
LOCATION:Sunstone Bldg / Ground floor / Big Seminar Room B / 63 seats (I23.
 EG.102)\, ISTA
ORGANIZER:jgazsi@ist.ac.at
SUMMARY:Eduardo Fernández Ortuño: Don't Put All Your Eggs in the Neoc
 ortex: How the small chick dorsal pallium challenges mammalian-centric vie
 ws on brain cortex evolution
URL:https://talks-calendar.ista.ac.at/events/6573
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