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DTSTART:20260329T030000
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DTSTAMP:20260728T111558Z
UID:6a6718ef86935830306549@ist.ac.at
DTSTART:20260903T134500
DTEND:20260903T150000
DESCRIPTION:Speaker: Eduardo Fernández Ortuño\nhosted by Lora Sweeney\nAb
 stract: The phenomenal size and cellular diversity of the human cerebral c
 ortex is the outcome of an elaborate developmental program sculpted by evo
 lutionary forces during millions of years. This evolution involved changes
  in neural progenitor cells\, which compared to reptiles and birds acquire
 d the capacity to generate larger numbers of neurons and in greater divers
 ity. Genetic causes of increased progenitor cell proliferation during evol
 ution have been identified\, but mechanisms involved in the diversificatio
 n of neural progenitor cells remain unknown. To address this question\, we
  performed the first integrated\, multi-level\, comparative study of neura
 l progenitor cells and lineages in the embryonic cortex across amniotes. T
 he analysis was focused on four strategic species that cover the spectrum 
 of cortical phenotypes: house snake\, chick\, mouse and ferret. Our result
 s revealed an unsuspected diversity of basal progenitor cell types in chic
 k\, superior to mouse and with similarities to the more complex ferret cor
 tex. Chick dorsal pallial progenitors included subapical and basal Radial 
 Glia\, and co-expressed Pax6 and Tbr2\, similar to ferret but unlike mouse
 \, where these are largely absent. Our findings challenge current concepts
  on the evolutionary trajectory of the cerebral cortex\, revealing a very 
 early diversification of cortical progenitor cell types in amniotes that p
 redated the last common ancestor of mammals and birds.
LOCATION:Sunstone Bldg / Ground floor / Big Seminar Room B / 63 seats (I23.
 EG.102)\, ISTA
ORGANIZER:jgazsi@ist.ac.at
SUMMARY:Eduardo Fernández Ortuño: Don't Put All Your Eggs in the Neocorte
 x: How the small chick dorsal pallium challenges mammalian-centric views o
 n brain cortex evolution
URL:https://talks-calendar.ista.ac.at/events/6573
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