BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20260329T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20261025T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260724T080343Z
UID:1786021200@ist.ac.at
DTSTART:20260806T150000
DTEND:20260806T160000
DESCRIPTION:Speaker: Peipeng Lin\nhosted by Charles Roques-Carmes\nAbstract
 : The hippocampal mossy fiber (MF) to CA3 pyramidal neuron synapse plays a
  key role in hippocampal information processing\, acting as a teacher syna
 pse that can conditionally drive postsynaptic firing and instruct informat
 ion storage in the downstream CA3 network. How the detonation properties o
 f this synapse are kept in check remains unclear. Our study demonstrates t
 hat CA3 stratum lucidum interneurons inhibit MF synaptic transmission via 
 presynaptic GABAB receptors. Pharmacological activation of these receptors
  by baclofen markedly reduced MF synaptic transmission\, switching the syn
 apse from a reliable conditional detonator into a coincidence-detecting su
 bdetonator. We identified a dual mechanism underlying this presynaptic inh
 ibition: a reduction in Ca² influx and\, more substantially\, a decrease 
 in the readily releasable pool of synaptic vesicles. Synaptically released
  GABA\, evoked by optogenetic stimulation of stratum lucidum interneurons 
 at in vivo-like frequencies\, produced comparable effects and further inte
 rfered with the stability of the short-term plasticity-associated vesicle 
 pool engram\, pointing to a physiological role for presynaptic inhibition.
  Expansion microscopy showed that interneuron terminals are positioned in 
 close proximity to MF boutons\, providing a structural basis for GABA spil
 lover onto presynaptic receptors. Together\, our findings reveal how inter
 neuron activity calibrates synaptic efficacy and plasticity at MF synapses
  through presynaptic inhibition\, with implications for memory encoding in
  the hippocampal trisynaptic circuit.
LOCATION:Central Bldg / O1 / Lecture Hall (I02.O1.014) and Zoom\, ISTA
ORGANIZER:
SUMMARY:Peipeng Lin: Thesis Defense:  	Calibrating the Teacher Synapse: Mec
 hanisms and Functional Significance of Presynaptic Inhibition at Hippocamp
 al Mossy Fiber Synapses
URL:https://talks-calendar.ista.ac.at/events/6569
END:VEVENT
END:VCALENDAR