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DTSTART:20170326T030000
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DTSTART:20171029T020000
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DTSTAMP:20260428T112240Z
UID:59393f5e76582211814822@ist.ac.at
DTSTART:20170614T160000
DTEND:20170614T170000
DESCRIPTION:Speaker: Zijun Sun\nhosted by Carl-Philipp Heisenberg\nAbstract
 : Throughout development\, tissues undergo complex morphological changes\,
  resulting from cellular mechanics that evolve over time and in three-dime
 nsional space. During Drosophila germ-band extension (GBE)\, cell intercal
 ation is the key mechanism for tissue extension\, and the associated apica
 l junction remodelling is driven by polarized myosin II-dependent contract
 ion. However\, the contribution of the basolateral cellular mechanics to G
 BE remains poorly understood. Here\, we characterize how cells coordinate 
 their shape from apical to basal side during rosette formation\, a hallmar
 k of cell intercalation. Basolateral rosette formation is driven by cells 
 mostly located at the dorsal/ventral part of the rosette. These cells exhi
 bit actin-rich wedge-shaped basolateral protrusions and migrate towards ea
 ch other. Surprisingly\, the formation of basolateral rosettes precedes th
 at of the apical rosettes. We further show that basolateral rosette format
 ion is independent of apical contractility\, but requires Rac1-dependent p
 rotrusive motility. Furthermore\, we identified Src42A as a regulator of b
 asolateral rosette formation. Our data show that in addition to apical con
 traction\, active cell migration driven by basolateral protrusions plays a
  pivotal role in rosette formation\, contributing to GBE.\n
LOCATION:Experimental Biology Room (I04.2OG - LAB)\, ISTA
ORGANIZER:lalesch@ist.ac.at
SUMMARY:Zijun Sun: Basolateral protrusion and apical contraction cooperativ
 ely drive Drosophila germ-ban extension
URL:https://talks-calendar.ista.ac.at/events/656
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