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DTSTART:20170326T030000
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DTSTART:20171029T020000
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DTSTAMP:20260428T112239Z
UID:5937e7bea3e91252302034@ist.ac.at
DTSTART:20170607T150000
DTEND:20170607T160000
DESCRIPTION:Speaker: Loic Dupré\nhosted by Michael Sixt\nAbstract: The mot
 ility of lymphocytes is intimately related to their immune surveillance fu
 nction. Lymphocytes alternate between phases of individual cell exploratio
 n across tissues and phases of prolonged cell:cell interaction during acti
 vation and function. We are exploring how diversified lymphocyte motility 
 behaviors emerge from the capacity of those cells to integrate signals fro
 m their environment\, including extracellular matrix components\, chemokin
 es\, neighbor cells and antigen-presenting cells. In a first part of the s
 eminar\, I will show how lymphocytes adapt their motility to extra-cellula
 r matrix composition by adopting different types of random walks. At high 
 cell density\, matrix interaction conditions the self-assembly of lymphocy
 tes into homotypic clusters endowed with collective coordination. Such beh
 avioral plasticity is controlled by adhesive and protrusive actin cytoskel
 eton pools\, respectively. In a second part\, I will focus on the adhesive
  mechanisms that specifically regulate the dynamic interaction between cyt
 otoxic T lymphocytes and target cells. A concentric synapse is assembled a
 t the cell:cell interface via the organization of a belt of high-affinity 
 LFA-1 integrin nanoclusters. Such topography is maintained by interaction 
 with the actin cytoskeleton and allows polarized delivery of lytic granule
 s towards the target cell. Those aspects of lymphocyte motility tuning wil
 l be further discussed in the context of primary immune deficiencies and l
 eukemia.\n
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:lalesch@ist.ac.at
SUMMARY:Loic Dupré: Adaptative migration of lymphocytes in the context of 
 cell:matrix and cell:cell interactions
URL:https://talks-calendar.ista.ac.at/events/655
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