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DTSTART:20260329T030000
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DTSTAMP:20260619T144025Z
UID:6a313b62abbad282106005@ist.ac.at
DTSTART:20260629T140000
DTEND:20260629T150000
DESCRIPTION:Speaker: Morgan Chabanon\nhosted by Jérémie Palacci\nAbstract
 : Transport phenomena in biological systems are essential for life-sustain
 ing functions. Here we propose to approach biological materials such as ti
 ssues\, biofilms and cells as porous media.We will first focus on the pass
 ive transport of macromolecules in the intracellular space\, involved in f
 unctions such as cell migration\, blebbing and apoptosis. While intracellu
 lar crowding significantly impacts macromolecule mobility\, the mechanisms
  by which cytoplasmic structures influence diffusion remain unclear. We pr
 opose a multiscale diffusion model based on an upscaling method developed 
 for porous media. Model predictions\, compared to experimental measurement
 s in live cells\, highlight two key diffusion reduction mechanisms: tortuo
 sity and hydrodynamic drag. Importantly\, we find that effective cytosolic
  diffusivity depends on intracellular obstacle volume fraction rather than
  specific cellular regions.We will then consider suspensions of motile bac
 teria in porous media\, relevant for soil bioremediation and biomedical ap
 plications. In confined environments at high cell density\, these suspensi
 ons behave as active fluids displaying self-sustained coherent or chaotic 
 flows. We use a continuum framework derived from FokkerPlanck descriptions
  to predict emerging flows in channels with different pore geometries as a
  function of activity and pressure gradient. Numerical results show a devi
 ation from Darcy law\, which we relate to an activity enhanced permeabilit
 y.Altogether\, these results demonstrate the potential of porous media mod
 eling to better understand transport phenomena in living matter across sca
 les and systems.
LOCATION:Moonstone Bldg / Ground floor / Seminar Room F (I24.EG.030f)\, IST
 A
ORGANIZER:cpetz@ist.ac.at
SUMMARY:Morgan Chabanon: Transport in porous media modelling of intracellul
 ar diffusion and active bacteria suspensions
URL:https://talks-calendar.ista.ac.at/events/6524
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