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DTSTART:20260329T030000
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DTSTAMP:20260513T190615Z
UID:1778065200@ist.ac.at
DTSTART:20260506T130000
DTEND:20260506T160000
DESCRIPTION:Speaker: David Vijatovic\nhosted by Amelia Douglass\nAbstract: 
 Motor circuits must generate distinct patterns of movement while adapting 
 to developmental changes in body form and behavioral demands. Frog metamor
 phosis provides a unique opportunity to study this process\, as Xenopus la
 evis transitions from axial\, tail-based swimming to limb-based locomotion
 . This work investigates how spinal circuits are molecularly organized and
  functionally reorganized during this transition.I examine how spinal neur
 on composition changes across metamorphosis\, showing that cell type diver
 sity increases with the emergence of limb movement. In particular\, inhibi
 tory V1 interneurons and motor neurons expand and diversify into transcrip
 tionally defined populations resembling those described in mammals. These 
 findings support conserved organizational principles of vertebrate spinal 
 circuits and link cell type diversification to the emergence of more compl
 ex motor behaviors. I further develop viral and optical approaches to prob
 e how these molecularly defined circuits are functionally reorganized duri
 ng this transition.Together\, these findings establish Xenopus laevis as a
  powerful model for linking molecular identity\, circuit dynamics\, and be
 havior across vertebrate development.
LOCATION:Sunstone Bldg / Ground floor / Big Seminar Room A / 27 seats (I23.
 EG.102)\, ISTA
ORGANIZER:
SUMMARY:David Vijatovic: Thesis Defense:Dissecting molecular and functional
  basis of motor control in Xenopus laevis frog
URL:https://talks-calendar.ista.ac.at/events/6442
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