BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20170326T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20171029T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260428T111848Z
UID:5925740cd0c56797276493@ist.ac.at
DTSTART:20170529T103000
DTEND:20170529T113000
DESCRIPTION:Speaker: Margit Silke Müller\nhosted by Martin Loose\nAbstract
 : Astrocytes are the most abundant cell type in human brain. One of their 
 main\nfunctions is metabolic support of neurons\, which they achieve despi
 te having a very high \nmetabolic turnover themselves. In recent years we 
 have discovered new mechanisms of \nregulation and self organization of as
 trocytic glucose metabolism\, which constitutes the\nmain source of both a
 strocytic ATP and substrates provided to neurons.\nAstrocytic glycogen\, t
 he cellular storage form of glucose\, constitutes a highly \ndynamic molec
 ule\, serving as a source of metabolic energy as well as contributing to \
 nneurotransmitter synthesis. Our data suggests a new role for astrocytic g
 lycogen\, in \nenergetically supporting ER Ca2+-homeostasis. Furthermore\,
  our results indicate that the \ntwo astrocytic isoforms of the glycogen d
 egrading enzyme glycogen phosphorylase are \ndifferentially regulated\, fa
 cilitating a glycogenolytic response to distinct metabolic demands.\nGluco
 se-6-Phosphatase (G6PC) is an ER luminal enzyme that in glucose-releasing 
 \ncells catalyses the dephosphorylation of glucose-6-phosphate\, allowing 
 glucose to be \nreleased by the cell. G6PC3 is the ubiquitous isoform of G
 6PC\, expressed throughout most \ncell types and tissues\, yet its role in
  non glucose-releasing cells remains unknown. However\, \nmutations in the
  G6PC3 gene cause severe congenital neutropenia and about half of the \npa
 tients suffer from developmental brain defects. We have investigated the f
 unction of G6PC3 in astrocytes\, using both human cells and rodent tissue.
  Our results suggest a  previously unknown pathway for astrocytic glucose 
 metabolism.
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Margit Silke Müller: Spatiotemporal organization of glucose metabo
 lism and cell signalling in astrocytes
URL:https://talks-calendar.ista.ac.at/events/641
END:VEVENT
END:VCALENDAR