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DTSTART:20260329T030000
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DTSTAMP:20260414T232704Z
UID:1777017600@ist.ac.at
DTSTART:20260424T100000
DTEND:20260424T110000
DESCRIPTION:Speaker: Raffaele Coray\nhosted by Alicia Michael\nAbstract: Cr
 yo-electron tomography (cryo-ET) enables three-dimensional visualization o
 f macromolecular complexes in near-native conditions\, but analyzing these
  datasets remains challenging due to structural heterogeneity and the comp
 lexity of the sample context. I will present context-aware template matchi
 ng\, an approach that leverages sample features\, such as membranes and su
 pporting geometries\, to improve particle identification. I will illustrat
 e this method using retromer-coated membrane tubules\, showing how templat
 e matching\, in conjunction with subtomogram averaging\, neighborhood anal
 ysis\, and heterogeneity analysis\, can reveal distinct classes of arch ar
 rangements and global coating patterns. This example demonstrates how inco
 rporating contextual information can enhance structural interpretation\, p
 roviding a framework for studying complex membrane-associated assemblies i
 n cryo-ET datasets. 
LOCATION:Moonstone Bldg / Ground floor / Seminar Room G\, ISTA
ORGANIZER:alicia.michael@ista.ac.at
SUMMARY:Raffaele Coray: Context-Aware Template Matching for Structural Anal
 ysis of Membrane-Assembled Retromer Coats
URL:https://talks-calendar.ista.ac.at/events/6405
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