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DTSTART:20260329T030000
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DTSTAMP:20260424T143237Z
UID:68776ee57aa4b682558249@ist.ac.at
DTSTART:20260528T110000
DTEND:20260528T120000
DESCRIPTION:Speaker: Mitja Drab\nhosted by Andela Saric\nAbstract: Biologic
 al membranes are active\, multicomponent systems whose shape emerges from 
 a complex interplay between curvature-inducing inclusions\, in-plane order
 ing\, and cytoskeletal forces. In this talk\, I present a numerical framew
 ork for modeling closed membranes populated by curved anisotropic componen
 ts that interact via nematic alignment and couple to active forces. Our si
 mulations reveal a rich landscape of membrane morphologies arising from th
 e competition between intrinsic curvature\, nematic interactions\, and act
 ive stresses. We show how nematic alignment organizes curved inclusions in
 to defect structures that localize in regions of high curvature\, thereby 
 guiding membrane remodeling and stabilizing complex shapes such as tubules
 \, necks\, and pearled structures . Active forces further drive the system
  out of equilibrium\, enabling transitions to morphologies that are inacce
 ssible in passive systems\, including flattened\, protrusive\, and dynamic
 ally fluctuating states. These results provide a unified physical picture 
 of how curvature\, orientational order\, and active forces cooperate to co
 ntrol membrane shape\, with implications for processes ranging from endocy
 tosis and phagocytosis to cell spreading and motility.
LOCATION:Office Bldg West / Ground floor / Heinzel Seminar Room (I21.EG.101
 )\, ISTA
ORGANIZER:cpetz@ist.ac.at
SUMMARY:Mitja Drab: Numerical Modeling of Nematic Membranes with Active Cur
 ved Anisotropic Inclusions
URL:https://talks-calendar.ista.ac.at/events/6382
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