BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20170326T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20171029T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260427T153736Z
UID:5925841166872938374124@ist.ac.at
DTSTART:20170529T113000
DTEND:20170529T124500
DESCRIPTION:Speaker: Stanislav Shvartsman\nhosted by Ani Kicheva\nAbstract:
  Studies in Drosophila provided key insights into the general principles o
 f pattern formation in developing embryos. For instance\, the regulatory l
 ogic of the dorsoventral patterning in Drosophila is strikingly similar to
  the logic uncovered in patterning of the vertebrate neural tube. We are b
 eginning to use Drosophila as a new model for the mechanistic studies of h
 uman developmental defects. I will present our recent work in this directi
 on\, focusing on a large class of developmental abnormalities that are cau
 sed by the germline mutations in the highly conserved RAS signaling pathwa
 y. Our approach relies on the quantitative analysis of the ways in which e
 ndogenous patterning processes in Drosophila are affected by introducing t
 he mutations identified in humans. Surprisingly\, we find that mutations t
 hat are strongly activating in the test tube can cause both gain- and loss
 -of-function phenotypes in vivo\, underscoring the nontrivial connections 
 between sequence changes in components of the regulatory networks and the 
 emerging structural and functional defects.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:akicheva@ist.ac.at
SUMMARY:Stanislav Shvartsman: Quantitative Biology of Developmental Defects
URL:https://talks-calendar.ista.ac.at/events/638
END:VEVENT
END:VCALENDAR