BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20260329T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20261025T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260505T191721Z
UID:69c104cda01c7847075710@ist.ac.at
DTSTART:20260512T140000
DTEND:20260512T150000
DESCRIPTION:Speaker: Sashi Weerawarana\nhosted by Alicia Michael and Floria
 n Schur\nAbstract: All living beings must package and compact their DNA to
  protect genetic material and regulate genome access. In my thesis work\, 
 I investigate genome organization in mitochondria\, bacteria\, and viruses
 . Mitochondria utilize the HMG-box protein TFAM to fulfill this vital role
 \, whereas bacteria and viruses employ histone proteins that adopt differe
 nt binding modes. The central focus of this talk is TFAM-mediated DNA comp
 action. Using a wide array of biochemical methods and structural biology a
 pproaches\, I show that TFAM compacts DNA into homogenous higher-order com
 plexes that exhibit continuous conformational dynamics. The talk also pres
 ents cryo EM data revealing distinct strategies utilized by bacterial hist
 ones from Bdellovibrio bacteriovorus and Leptospira interrogans to compact
  DNA and highlights unique structural features of the Medusavirus medusae 
 nucleosome. Together\, this work reveals diverse mechanisms of genome comp
 action across organelles and domains of life.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:jgazsi@ist.ac.at
SUMMARY:Sashi Weerawarana: Genome organization in mitochondria\, bacteria\,
  and viruses
URL:https://talks-calendar.ista.ac.at/events/6371
END:VEVENT
END:VCALENDAR