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DTSTART:20260329T030000
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DTSTAMP:20260414T232702Z
UID:69c104cda01c7847075710@ist.ac.at
DTSTART:20260512T140000
DTEND:20260512T150000
DESCRIPTION:Speaker: Sashi Weerawarana\nhosted by Florian Schur\nAbstract: 
 All living beings must package and compact their DNA to protect genetic ma
 terial and regulate genome access. In my thesis work\, I investigate genom
 e organization in mitochondria\, bacteria\, and viruses. Mitochondria util
 ize the HMG-box protein TFAM to fulfill this vital role\, whereas bacteria
  and viruses employ histone proteins that adopt different binding modes. T
 he central focus of this talk is TFAM-mediated DNA compaction. Using a wid
 e array of biochemical methods and structural biology approaches\, I show 
 that TFAM compacts DNA into homogenous higher-order complexes that exhibit
  continuous conformational dynamics. The talk also presents cryo EM data r
 evealing distinct strategies utilized by bacterial histones from Bdellovib
 rio bacteriovorus and Leptospira interrogans to compact DNA and highlights
  unique structural features of the Medusavirus medusae nucleosome. Togethe
 r\, this work reveals diverse mechanisms of genome compaction across organ
 elles and domains of life.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:jgazsi@ist.ac.at
SUMMARY:Sashi Weerawarana: Genome organization in mitochondria\, bacteria\,
  and viruses
URL:https://talks-calendar.ista.ac.at/events/6371
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