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TZID:Europe/Vienna
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DTSTART:20260329T030000
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DTSTART:20251026T020000
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BEGIN:VEVENT
DTSTAMP:20260310T214608Z
UID:6973503e778d2133173368@ist.ac.at
DTSTART:20260210T110000
DTEND:20260210T120000
DESCRIPTION:Speaker: Jens Elgeti\nhosted by Edouard Hannezo\nAbstract: Mech
 anical forces influence cellular decisions to grow\, die\, or differentiat
 e\, through largely mysterious mechanisms. Separately\, changes in resting
  membrane potential have been observed in development\, differentiation\, 
 regeneration\, and cancer. We demonstrate that membrane potential is an im
 portant mediator of cellular response to mechanical pressure. We show that
  mechanical forces acting on the cell change cellular biomass density\, wh
 ich\, in turn\, alters membrane potential. Membrane potential then regulat
 es cell number density in epithelia by controlling cell growth\, prolifera
 tion\, and cell elimination. I will present the experimental evidence that
  lead to the discovery\, but mainly focus on the physical mechanism based 
 on osmotic stresses and charge balance. I will introduce simulations based
  on this mechanism\, and show their predictions and experimental verificat
 ion.[1] Mukherjee\, Huang\, Elgeti\, Basan. Cell 189\, 143 (2026)
LOCATION:Sunstone Bldg / Ground floor / Big Seminar Room B / 63 seats (I23.
 EG.102)\, ISTA
ORGANIZER:cpetz@ist.ac.at
SUMMARY:Jens Elgeti: Membrane potential mediates the cellular response to m
 echanical pressure – insights from simulations
URL:https://talks-calendar.ista.ac.at/events/6271
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