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DTSTAMP:20260424T063026Z
UID:1770642000@ist.ac.at
DTSTART:20260209T140000
DTEND:20260209T150000
DESCRIPTION:Speaker: Zuzana Dunajova\nhosted by Carrie Bernecky\nAbstract: 
 How is self-organization in biological systems shaped by the geometry of i
 ndividual units and the structure of their environment? In this thesis\, w
 e combine minimal active-matter models with bottom-up in vitro experiments
  to uncover physical principles underlying emergent biological behavior ac
 ross scales. At the subcellular scale\, we show how the shape and mechanic
 s of treadmilling FtsZ filaments control large-scale pattern formation\, w
 hich is relevant for bacterial cytokinesis. We find that filament flexibil
 ity and activity-driven straightening cause a shift from chiral to nematic
 -like self-organization. At the cellular scale\, we investigate how cancer
  cells migrate through complex microenvironments. Strikingly\, we find tha
 t geometric disorder alone can induce a transition from collective to sing
 le-cell invasion and shift the universality class of interface dynamics. F
 inally\, we study how cell-intrinsic geometry and chirality influence coll
 ective motion. Using a minimal model of rotating motile cells\, we show th
 at confinement can promote chiral flows\, while in dense unconfined system
 s chirality becomes masked even before the onset of jamming transition. Ov
 erall\, this work uncovers how geometric constraints - embedded in the int
 rinsic architecture of an active filament or encoded in the complexity of 
 a microenvironment - couple to active forces to generate different classes
  of complex behaviors.
LOCATION:Central Bldg / O1 / Mondi 3 (I01.O1.010) \, ISTA
ORGANIZER:
SUMMARY:Zuzana Dunajova: Thesis Defense: Geometry-driven self-organization 
 of migrating cells and chiral filaments
URL:https://talks-calendar.ista.ac.at/events/6252
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