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DTSTAMP:20260424T143452Z
UID:6964a817f3eba980251668@ist.ac.at
DTSTART:20260129T130000
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DESCRIPTION:Speaker: Richard Wong\nhosted by Martin Loose\nAbstract: Biomol
 ecular dynamics govern cellular architecture\, homeostasis\, and adaptive 
 responses to environmental stress. While structural biology has been trans
 formative in defining molecular form and function\, many essential process
 es are driven by transient and mechanically coupled dynamics that remain d
 ifficult to capture. Cryo-EM and X-ray crystallography provide exquisite s
 tructural detail but are limited in temporal resolution and often require 
 non-physiological conditions\, whereas spectroscopic approaches such as FR
 ET and NMR lack direct real-time visualization of structural transitions. 
 High-speed atomic force microscopy (HS-AFM) bridges this gap by enabling r
 eal-time nanoimaging of biomolecular dynamics under near-physiological con
 ditions with high spatiotemporal resolution and minimal perturbation. In t
 his talk\, I will show how HS-AFM moves us beyond static snapshots toward 
 living structural landscapes\, focusing on nuclear pore complexes (NPCs)\,
  chromatin organization\, microtubule dynamics\, and extracellular vesicle
 s. Our work reveals that NPCs are highly dynamic\, mechanically adaptive a
 ssemblies that regulate nucleocytoplasmic transport while shaping perinucl
 ear chromatin architecture. HS-AFM captures transient interactions between
  NPCs and chromatin-associated proteinsgenome guardians coordinating trans
 cription\, DNA repair\, and stress responses. Extending this dynamic view 
 to cytoskeletal systems\, we also visualize asymmetric protofilament failu
 re and spontaneous rescue events during microtubule disassembly\, revealin
 g unexpected stabilization mechanisms. Conceptually\, this nanoscale persp
 ective aligns with active-matter studies showing how single-filament prope
 rtiessuch as flexibility\, density\, and chiralitygovern emergent mesoscop
 ic order\, exemplified by chiral and nematic phase transitions in reconsti
 tuted cytoskeletal filaments. Together\, these findings demonstrate how na
 noscale dynamics at organelle and filament interfaces integrate transport\
 , genome regulation\, and cytoskeletal remodeling\, providing a framework 
 for understanding disease-relevant processes in cancer\, neurodegeneration
 \, infertility\, and viral infection.
LOCATION:Moonstone Bldg / Ground floor / Seminar Room G (I24.EG.030g)\, IST
 A
ORGANIZER:mloose@ist.ac.at
SUMMARY:Richard Wong: Zooming Through the Cellular Labyrinth: Journeys to t
 he Nuclear Pore and Chromatin
URL:https://talks-calendar.ista.ac.at/events/6239
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