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TZID:Europe/Vienna
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DTSTART:20260329T030000
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DTSTART:20251026T020000
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DTSTAMP:20260424T153005Z
UID:68776e25ec455620825225@ist.ac.at
DTSTART:20260115T110000
DTEND:20260115T120000
DESCRIPTION:Speaker: Alexander Dear\nhosted by Andela Saric\nAbstract: How 
 do competing pathways\, surface catalysis\, and phase transitions shape se
 lfassembly?In this seminar\, I will first show how analytical solutions to
  rate laws enable mechanistic dissection of how different selfassembly pat
 hways compete. These solutions reveal how reaction cascades can spread fro
 m one system to another via crosscatalysis and crossinhibition\, providing
  insight into links between amyloid disorders.I will then show how applyin
 g precise thermodynamic reasoning to the largely experimentdriven field of
  protein aggregation exposes the central role of morphological defects in 
 the selfreplication of amyloid fibrils and the influence of thirdparty sur
 faces in selfassembly more generally.Finally\, I will show how combining a
 nalytical solutions with thermodynamic reasoning reveals hidden roles of p
 hase transitions within protein selfassembly. Competition between fibrils 
 and other phases leads to phenomena such as hysteresis and biochemical mem
 ory storage by reversible amyloids\, but can also trigger neurodegenerativ
 e disease.
LOCATION:Office Bldg West / Ground floor / Heinzel Seminar Room (I21.EG.101
 )\, ISTA
ORGANIZER:cpetz@ist.ac.at
SUMMARY:Alexander Dear: Hidden Mechanisms in Self-Assembly: Pathway Competi
 tion\, Surface Catalysis\, and Phase Transitions
URL:https://talks-calendar.ista.ac.at/events/6213
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