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DTSTART:20260329T030000
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DTSTAMP:20260415T110135Z
UID:693064adc7e28739553792@ist.ac.at
DTSTART:20251211T140000
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DESCRIPTION:Speaker: Thomas Böttcher\nhosted by Leonid Sazanov\nAbstract: 
 This talk will feature our recent advances in the study of bacterial 2-alk
 yl-4(1H)-quinolones and their N-oxide derivatives. These compounds\, produ
 ced by various bacterial species\, serve a broad range of functions\, from
  signaling to antimicrobial activities. Beyond enhancing the mechanistic u
 nderstanding of their biosynthesis and phylogeny\, I will focus on their p
 otential as novel scaffolds for highly specific\, ultra-narrow-spectrum an
 tibiotics. Our research demonstrates that NQNO\, along with its synthetic 
 derivatives\, can disrupt the electron transport chain and subsequently de
 stabilize a toxin-antitoxin system of the human-specific pathogen Neisseri
 a gonorrhoeae. This system is present in pathogenic Neisseria gonorrhoeae 
 but absent in commensal strains\, making our compounds highly selective in
  targeting the pathogen.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:lsazanov@ist.ac.at
SUMMARY:Thomas Böttcher: Seminar by Thomas Böttcher
URL:https://talks-calendar.ista.ac.at/events/6206
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