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DTSTART:20260329T030000
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BEGIN:VEVENT
DTSTAMP:20260416T222457Z
UID:1764923400@ist.ac.at
DTSTART:20251205T093000
DTEND:20251205T103000
DESCRIPTION:Speaker: Marc Schmidt-Supprian\nhosted by Michael Sixt\nAbstrac
 t: Mast cells are ancient immune cells with key effector functions in alle
 rgic and anaphylactic reactions. Mast cells bind circulating IgE with thei
 r FCERIA surface receptor and thereby acquire a functional antigen recepto
 r module. As mast cells and their surface-bound IgE are long-lived\, their
  allergic antigen reactivity reflects the current and historical IgE produ
 ction. Upon allergic antigen encounter\, mast cells release a large number
  of pre-formed and newly produced bioactive substances from their granules
  in a process termed degranulation. Antigen-induced IgE:FCERI proximal sig
 naling has been elucidated in great detail. However\, downstream signals r
 egulating degranulation are not well understood.We performed systematic pr
 oteomic analyses of kinetic mast cell degranulation combined with loss-of-
 function CRISPR screens to shed light on these processes.
LOCATION:Mondi 2\, Central Building\, ISTA
ORGANIZER:
SUMMARY:Marc Schmidt-Supprian: Proteogenomic Analyses of Allergic Mast Cell
  Degranulation
URL:https://talks-calendar.ista.ac.at/events/6176
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